Evaluation of Wound Healing Effect of Curcumin Loaded OPL - Springer The authors declare no conflict of interest. Effects of nutritional status on wound healing. The authors declare no competing interests. Hunt T.K., Ehrlich H.P., Garcia J.A., Dunphy J.E. This review summarizes and discusses recently published papers on the effects of curcumin on skin wound healing. Curcumin-induced angiogenesis hastens wound healing in diabetic rats. In addition to these factors, a reduction in active growth factors may partially explain why certain wounds fail to heal. Liposomal carrier, nanocapsule and micelles are some of the other drug delivery vehicles used with curcumin [32,33,34,35,36]. This has led to widespread use of numerous plants and their derivatives in the Asian and African subcontinents. sharing sensitive information, make sure youre on a federal In fact, fibroblast migration depends on several factors that cannot be entirely mimicked with in vitro models, such as cell-environment interactions and homeostatic mechanisms [17]. Collaboration network of contributing countries. Meiyanto, E., and Jenie, R.I. are the second most collaborative partners with a link strength of 12, followed by Putri, H. and Liu, Y with link strength of 10. Despite the large number of. ), 2General and Emergency Surgery Department, Garibaldi Hospital, Piazza Santa Maria di Ges, 95100 Catania, Italy; ti.liamtoh@alove_eppesuig, 3Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via Plebiscito 628, 95124 Catania, Italy; ti.tcinu@elisabg. In terms of article counts, India came in front with the largest circle, followed by China, the United States, and so forth. Curcumin as a wound healing agent - PubMed Curcumin: A novel therapeutic for burn pain and wound healing Herbal Medicine: Biomolecular and Clinical Aspects. In the proliferative and remodeling phases, protein-energy deficiency may also decrease fibroblast activity, delaying angiogenesis and reducing collagen formation [8]. Curcumin has prospective wound-healing activity against chronic wounds. Moreover, in chronic wounds, fibroblasts show a decreased potential of proliferation accompanied by an increased number of senescent cells that might impair responsiveness to growth hormones [22]. Moreover, exponential regression analysis suggests that India and USA growth can be fitted toy=(1.91261.0470)x andy=(1.64131.0357)x respectively. This study offers a quantitative perspective based on bibliometric data in light of the significance of the research on curcumin as a potential wound-healing agent. In terms of citations, India is second (11,361). Tejada S., Manayi A., Daglia M., FNabavi S., Sureda A., Hajheydari Z., Gortzi O., Pazoki-Toroudi H., MNabavi S. Wound healing effects of curcumin: A short review. We observed faster wound closure of punch wounds in curcumintreated animals in . Ardawi M.S. More recently, it has been demonstrated that curcumin might modulate physiological and molecular events involved in the inflammatory and proliferative phases of the wound healing process [60]. IJMS | Free Full-Text | Nutrition and Wound Healing: An Overview - MDPI Nutrition and Wound Healing: An Overview Focusing on the Beneficial PDF | Curcumin or turmeric is the active constituent of Curcuma longa L. . We have summarized that protein loss may negatively affect the whole immune process, while adequate intake of carbohydrates is necessary for fibroblast migration during the proliferative phase. As for arginine, benefits of glutamine supplementation are still controversial [43] and confounded by the combinations of supplements [44]. Neutrophils and macrophages recruited to the wound remove foreign particles and produce a wide range of growth factors and cytokines that promote fibroblast migration and proliferation [17]. In general, losing 10% lean mass is associated with impaired immunity and increased risk of infection. Here, we provide an overview of the effects of malnutrition and specific nutrients on this process, focusing on the beneficial effects of curcumin. While early topics focused on conventional medical uses of curcumin in wound healing, more current issues pertain to genetic engineering and biotechnology to improve new medication delivery systems. Phases and specific events of the wound healing process. Curcumin has been studied as a therapeutic drug for wound healing because of its anti-inflammatory, anti-oxidant, and anti-bacterial activities. Then, manual screening was used to enhance the quality of the data by reading the entire texts and examining the content of the articles to filter out the unnecessary ones. Malnutrition. Formulation and bacterial phototoxicity of curcumin loaded alginate foams for wound treatment applications: Studies on curcumin and curcuminoides XLII. Curcumin nanoparticles incorporated in PVA/collagen composite films The Cellular and Molecular Research Center of Iran University of Medical Sciences is the most collaborative, with 8 different collaborators followed by Biotechnology Research Center (5), Neurogenic Inflammation Research Center (5) and the School of Pharmacy (5). Iyer V., Pumiglia K., DiPersio C.M. 1Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia, University of Catania, Via S. Sofia 87, 95123 Catania, Italy; ti.tcinu@attihcrab.anitram (M.B. Top 10 authors from an article count perspective. Curcumin, a natural extract from the rhizomes of Curcuma longa, is also known as a curcuminoid. It has been noted that curcumin as a word has only been used since 2015, while curcuma longa and curcuma have been used for a very long time. The top 10 journals in terms of the article count on the use of curcumin for wound healing were responsible for 14.48 percent of the corpus (Table 1) and 16.07 percent of the total citation count. Curcumin: Total-Scale Analysis of the Scientific Literature. The aim of the present study is to present a bibliometric analysis of the recent literature concerning the wound-healing properties of curcumin. The green cluster consists of four research institutions, out of which three are from Mashhad University of Medical Sciences (Biotechnology Research Center, Neurogenic Inflammation Research Center and School of Pharmacy) and Halal Research Centre, Iran. and Bayat, M. are the closest partners with highest link strength of 15 among each other. Wei Y., Yuan X., Wu G., Yang L. Climate change risk assessment: A bibliometric analysis based on web of science. Wound healing implicates several biological and molecular events, such as coagulation, inflammation, migration-proliferation, and remodeling. All authors have read and agreed to the published version of the manuscript. Enoch S., Grey J.E., Harding K.G. The International Journal of Biological Macromolecules published the most articles (44), and it also received the most citations (2012). Oxidant signaling in lung cells. Blass S.C., Goost H., Tolba R.H., Stoffel-Wagner B., Kabir K., Burger C., Stehle P., Ellinger S. Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: A PRCT. Barchitta M., Maugeri A., Favara G., Magnano San Lio R., Evola G., Agodi A., Basile G. Nutrition and wound healing: An overview focusing on the beneficial effects of curcumin. Curcumin improves wound contraction during. Conceptualization: F.F., S.S.S. Extracellular matrix proteins are crucial in this phase because they provide substrates for cell migration and structures that restore the function and integrity of the tissue [18]. Interestingly, its pleiotropic effect on several signaling pathwaysby modulating cellular regulatory systems, such as NF-B, AKT, growth factors, and Nrf2 transcription factor [92,93,94,95]might be explained by its well-established role in epigenetic mechanisms, such as DNA methylation and histone modification [96]. Roy S., Khanna S., Nallu K., Hunt T.K., Sen C.K. In wounds, it protects against the risk of infectious and inflammatory complications by up-regulating the expression of heat shock proteins [40]. However, to what extent they support wound healing process remains unclear until now. Trend analysis of publications per year showing an exponential growth in annual publications through time. The Wound Healing Process: An Overview of the Cellular and Molecular See Full PDF Download PDF. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species Molecular and Cellular Biochemistry Authors: Manikandan Panchatcharam University of Kentucky. the contents by NLM or the National Institutes of Health. FOIA The spice Curcuma longa is widely used throughout the world, including India. Choma D.P., Pumiglia K., DiPersio C.M. The natural medications for wound healingCurcumin, Aloe-Vera and GingerDo not induce a significant effect on the migration kinematics of cultured fibroblasts. Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Expression of hepatic antioxidant genes in l-thyroxine-induced hyperthyroid rats: Regulation by vitamin E and curcumin. Herbal treatments have been used to heal wound infections since ancient times. Curcumin prevents maleate-induced nephrotoxicity: Relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. Zheng Q.T., Yang Z.H., Yu L.Y., Ren Y.Y., Huang Q.X., Liu Q., Ma X.Y., Chen Z.K., Wang Z.B., Zheng X. Synthesis and antioxidant activity of curcumin analogs. To achieve the aim of the study, the data is analyzed using standard parameters such as the annual publication, contributing journals, countries, institutions and authors using SCOPUS analysis, VOSviewer and MS Excel software. An understanding of epigenetic regulation in the wound healing process is now becoming an attractive field of research [97], and more efforts should be made to uncover mechanisms underpinning beneficial effects of curcumin and other polyphenols [96,98]. Vitamin C is essential to counteract the production of free radicals in damaged cells, while its deficiency might increase the fragility of new vessels [50]. official website and that any information you provide is encrypted The https:// ensures that you are connecting to the We also used the search string cur-cum*, which ensures that curcumin as well as curcuma longa are included in the results. Ellinger S., Stehle P. Efficacy of vitamin supplementation in situations with wound healing disorders: Results from clinical intervention studies. In addition, curcumin appears to be beneficial for epithelialization [70] and for apoptotic processes that discard inflammatory cells from the wound site [88,89,90]. It acts on various stages of the natural wound healing process to hasten healing. To meet the increased need of energy, especially during the proliferative phase, wounds also metabolize carbohydrates and fats [26], which in turn are necessary for fibroblast and leukocyte activities, secretion of hormones and growth factors, and structural functions [29,30]. The current recommendation of vitamin C supplementation ranges from 500 mg/day in non-complicated wounds to 2 g/day in severe wounds [33]. (PDF) Curcumin in Wound Healing-A Bibliometric Analysis - ResearchGate Polymer-based materials loaded with curcumin for wound healing applications. As a library, NLM provides access to scientific literature. Sen C.K., Gordillo G.M., Roy S., Kirsner R., Lambert L., Hunt T.K., Gottrup F., Gurtner G.C., Longaker M.T. In wound patients with adequate protein intake, the recommended dose of arginine supplementation is 4.5 g/day, while it is useless in the context of protein deficiency [39]. The International Journal of Biological Macromolecules stands out as the most prolific publication source, having the most articles published (44) and also the most citations (2012), followed by the Journal of Ethnopharmacology (28 articles) and Current Pharmaceutical Design (20 articles), with 1231 and 812 citations, respectively. The recent research has been more focused on drug delivery systems using modern biotechnological techniques to enhance the specificity of the curcumin molecule toward the drug target. Table 2 shows the top 10 countries measured by article count, among which India ranked first, followed by China, USA, Iran, and Italy. Gopinath D., Ahmed M.R., Gomathi K., Chitra K., Sehgal P.K., Jayakumar R. Dermal wound healing processes with curcumin incorporated collagen films. Due to the relatively low level of collaboration across these institutes, initiatives to build deeper links may help this field advance in the future. For the purpose, curcumin-loaded chitosan and sodium alginate membranes were developed using microwave at fixed frequency of 2450 MHz, power 350 W for 60 s, and tested for their . Despite this evidence, the effect of macronutrient supplementation is currently controversial, raising the need for further research. Acceleration of wound repair by curcumin in the excision wound of mice exposed to different doses of fractionated radiation. Accordingly, curcumin recruits M2-like macrophages into white adipose tissues, thereby increasing the production of anti-inflammatory cytokines that are essential for the inflammatory response [62]. Among these, zinc is essential for DNA replication in cells with high cell division rates, such as inflammatory and epithelial cells, and fibroblasts. For instance, it has been demonstrated the beneficial effect of curcumin on the progression of endometriosis, a common disorder affecting women during reproductive age which shares some molecular events with wound healing (i.e., adhesion and proliferation, cellular invasion and angiogenesis) [14]. Curcumin: A review of its effects on human health. As discussed below, curcumin also plays a critical role during the proliferative phase. Curcumin as a wound healing agent. Given that protein-calorie deficiencies are further associated with weight loss and decreased lean body mass [27], their implications for wound patients should be also recognized. Effects of steroids and retinoids on wound healing. From a biomechanical perspective, it is specifically unclear whether fibroblast motility improves in the presence of any of these NMs. In wounded sites, curcumin might reduce inflammation caused by the activation of the NF-B pathway [64]. A Global Perspective on Wound Care. Topics shown in blue were prevalent at the beginning of the year 2000, green topics were more prevalent between 2015 and 2018, and yellow topics predominated in the years following 2018. Wu G., Bazer F.W., Davis T.A., Kim S.W., Li P., Marc Rhoads J., Carey Satterfield M., Smith S.B., Spencer T.E., Yin Y. Arginine metabolism and nutrition in growth, health and disease. Despite the large number of available reviews on this topic, a bibliometric tool-based meta-analysis is missing in the literature. In vitro and in vivo studies have demonstrated the antioxidant activities of curcumin conferred by its electron-donating groups (i.e., the phenolic hydroxyl group) [76]. Micronutrients involved in the wound healing process have been extensively reviewed [7,8,9,33]. Since NF-B has also several anti-oxidant targets, in 2004, Frey and Malik proposed a relationship between inflammation and oxidation during the wound healing process [69]. Martin P. Wound healingAiming for perfect skin regeneration. Role of arginine in superficial wound healing in man. During inflammation, the up-regulation of inflammatory mediators (i.e., cytokines and chemokines) activates NF-B, which in turn translocates to the nucleus [63]. To date, the effect of supplementation of essential fatty acids on wound healing is controversial. Curcumin is a naturally occurring polyphenol that can be found in the rhizome of Curcuma species [8], and it has a variety of properties including antimicrobial, antioxidant, and anti-inflammatory activities, making it particularly useful in the process of healing wounds [9]. When the gathered data is imported into the VOSviewer software, a total of 16,208 keywords appeared. Mohanty C., Das M., Sahoo S.K. Yeung A.W.K., Horbaczuk M., Tzvetkov N.T., Mocan A., Carradori S., Maggi F., Marchewka J., Sut S., DallAcqua S., Gan R.-Y., et al. government site. Treatment of a chronic hard-to-heal wound and its therapeutic impediments have always attracted great concern in health care and medical fields, bringing about substantial economically challenging burdens worldwide (1-5). Sustained wound healing activity of curcumin loaded oleic acid based polymeric bandage in a rat model. In addition to being antibacterial [13], antioxidant, and anti-inflammatory, curcumin also promotes tissue proliferation and remodeling, making it a highly potent healing agent. Asai A., Miyazawa T. Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma. Among the curcuminoids, curcumin is the powerful substance which possesses anti-inflammatory, analgesic and wound healing properties 13, 14 . Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? Curcumin, Aloe-vera and Ginger are popular natural medications (NMs) for treating wounds, however, the mechanisms by which these NMs apparently accelerate wound healing remain largely unknown. A trend analysis of publications each year is illustrated, displaying the pattern of articles published from 1942 to 2021. Wound Healing Effects of Curcumin: A Short Review - PubMed Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of. Durgaprasad S., Reetesh R., Hareesh K., Rajput R. Effect of topical curcumin preparation (BIOCURCUMAX) on burn wound healing in rats. According to the current analysis, Mashhad University of Medical Sciences, Shahid Beheshti University of Medical Sciences, the Ministry of Education of China, the Central Leather Research Institute of India, and the University of Sao Paulo are the top five institutions in terms of publications. There were 3658 organizations involved in publishing these articles in 159 different journals. 8600 Rockville Pike Mazzotta M.Y. Velnar T., Bailey T., Smrkolj V. The wound healing process: An overview of the cellular and molecular mechanisms. Curcumin as a wound healing agent - ScienceDirect ABC of wound healing. Rathore S., Mukim M., Sharma P., Devi S., Nagar J.C., Khalid M. Curcumin: A review for health benefits. Curcumin as Curecumin: From kitchen to clinic. One of the most investigated substances with pleiotropic effects in treating skin disorders is curcumin, the active ingredient of the medicinal plant Curcuma longa. An ideal wound-healing agent should have antimicrobial properties to keep the wound from getting infected, anti-inflammatory properties to lessen inflammation, and proliferative and regenerative properties to speed up the process of cell proliferation and tissue remodeling [11]. Beyond proteins, both carbohydrates and fats address increased energy needs to support inflammatory response, cellular activity, angiogenesis, and collagen deposition in the proliferative phase of healing process [26]. However, only 4 and 22 institutions, respectively, participated in more than 20 and 10 articles. 1Department of Zoology, Aligarh Muslim University, Aligarh 202002, India, 2Department of Computer Science and Engineering, Jamia Hamdard University, New Delhi 110062, India, 3College of Science and Arts, Najran University, Najran 11001, Saudi Arabia, 4School of Business, University of South-Eastern Norway, 3511 Hnefoss, Norway. An effective metric for assessing research collaboration is the level of academic cooperation [26]. 2023, Life. Despite the large number of available reviews on this topic, a bibliometric tool-based meta-analysis is missing in the literature. The most frequently used markers in bibliometric studiesarticle count, citation count and Hirsch index (H-index)were taken into consideration to measure the influence and impact of the scientific research conducted. Stadelmann W.K., Digenis A.G., Tobin G.R. China (18.76%240 articles) ranked the second in highest contribution, followed by the USA (12.77%164 articles), Iran (8.64%111 articles), and Italy (3.5%45 articles). A wound is a physical disruption of the skin architecture due to trauma resulting in fluid loss, injury and pain to the individual [].Wounds are classified as chronic and acute wounds based on their duration and the nature of the healing process [].Chronic wounds are injuries that fail to heal via the normal wound healing process . The academic level was also measured using the H-index from both a quality and a quantity perspective. Classification of Wounds and Phases of Wound Healing Process. Hence, further efforts are needed to improve our scientific understanding of the repair process and how that knowledge can be used to develop new approaches to treatment. Recently, various topical formulations of curcumin such as films, fibers, emulsion, hydrogels and different nanoformulations have been developed for targeted delivery of curcumin at wounded sites. The search results were limited to journal articles in English that were published until 2021. However, since 2015, wound healing has been used more frequently (702 times), making it the second most commonly occurring terminology after curcumin (922 occurrence). Russell L. The importance of patients nutritional status in wound healing. the contents by NLM or the National Institutes of Health. Fats have structural functions in the lipid bilayer of cell membranes during tissue growth. In general, vitamin A is topically administered for the care of dermatologic conditions due to its stimulating properties of fibroplasia and epithelialization [33]. Curcumin was widely utilized in traditional Indian . ; supervision: R.R.I. This is apparent from the fact that, while having much lower average citation rates per article than the United States (81.46), India (32.09) and China (26.44) are ranked second and third overall in terms of total citation counts. Non-surgical and drug treatments. 5 However, progress in . KEYWORDS curcumin, electrospinning, nanofiber, wound healing 1 INTRODUCTION The turmeric plant belongs to the ginger family and has been used for Nutrition for optimum wound healing. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (, wound, wound healing, diet, nutrition, micronutrients, macronutrients, curcumin, amino-acids, vitamins, minerals. Shepherd A.A. In line with the Special Issue Curcumin in Health and Disease, we have focused on the beneficial effects of curcumin, which exerts its anti-inflammatory and antioxidant properties during the different phases of the wound healing process [11]. Maugeri A., Barchitta M., Mazzone M.G., Giuliano F., Basile G., Agodi A. Resveratrol modulates. Keywords such as nanocomposite, nanofibre, nano material, biomechanics, hydrogel, emulsion and electrospinning techniques are found in the green cluster, which is devoted to biotechnology and drug delivery mechanics. Wound healing is a very complex natural process involving several interconnecting steps to restore the normal structural integrity and function of the damaged area. The red cluster includes five research institutions out of which three institutes were from Tehran University of Medical Sciences (Experimental Medicine Centre, Department of Pharmacology and Department of Medical Nanotechnology) and two institutes were from Iran University of Medical sciences (Cellular and Molecular Research Center and Department of Tissue Engineering and regenerative medicine).