German Rehabilitation Centers Booking Health (My ophthalmologist has basically told me there's nothing I can do and my RP has become more aggressive). Electroencephalography (EEG) was recorded for 2 min before and after each stimulation session using 16 electrodes (1020 system) with impedances <10k with eyes closed (at rest) in a darkened room. broad scope, and wide readership a perfect fit for your research every time. Fixation accuracy in eye-tracking during HRP. Data requests may be sent to imp@med.ovgu.de. Stimulation current strength was 125% of phosphene threshold recorded during 5 Hz stimulation. As recently shown by patients with optic nerve damage who suffer from desynchronization of spatial and temporal processing deficits of their brain functional networks [12, 29] the therapeutic effects of rtACS may be mediated by re-synchronizing the brain networks, which were desynchronized by the vision loss. Experts Debate Usefulness of Vision Restoration Therapy - Psychiatric Times Its close proximity to the clinic ensures both convenience and easy access during your treatment period. Jeli Twj znajomy dokona wpaty za pomoc udostpnionego przez Ciebie linku, wpata ta zostanie dodana do Twoich statystyk. Possible side effects were evaluated by a semi-structured daily interview that included queries on mild headache, discomfort, and vertigo as expected minor adverse events. For example, visual acuity did not change significantly (Table 3). Loss Of Vision | Post Tumor Optic Nerve Damage Treatment Most of the clinics are located near parks. No, Is the Subject Area "Functional electrical stimulation" applicable to this article? Post-intervention changes in the intact and residual visual field did not differ between groups. The EEG data were analyzed in 3 steps. How does Fedorov Restoration Therapy work? Contributed equally to this work with: Carolin Gall, Sein Schmidt . By nature I'm a very sceptical person and after finding their website I immediately assumed that it was some sort of scam. e0156134. We will assess whether your medical condition will respond favourably to treatment, and estimate the extent and nature of the benefits that can be expected. The beneficial functional consequence of rtACS for visual perception may possibly be explained by retinofugal entrainment and brain functional connectivity modulation [12, 16]. Theyve given me hope. Non-invasive current stimulation in vision recovery: a review of the Fedorov Restoration Therapy Furthermore, the optical nerve of the stimulated eye also receives parts of the stimulating current density magnitude as currents enter the inner skull. The rtACS-treated group had a mean improvement in visual field of 24.0% which was significantly greater than after sham-stimulation (2.5%). Coherence was calculated for each pair of channels ij and defined as follows: In this equation S denotes the spectrum of signals from two EEG channels i and j, for a given frequency bin f. Changes in spectral power of oscillatory brain activity and strength of functional connectivity over the visual cortex after the first stimulation session were then related to the primary outcome measure. Conceived and designed the experiments: CG SS BAS SAB SK MPS WP. Back pain and stiff neck were reported by one rtACS-subject on the first four stimulation days. Te informacje mog dotyczy Ciebie, Twoich preferencji lub urzdzenia i s uywane gwnie w celu zapewnienia dziaania witryny w oczekiwany sposb. Fedorov Restore Vision : r/RetinitisPigmentosa - Reddit Contributed reagents/materials/analysis tools: CG MB AM SS MD. Based on our deep comprehension of the vision restoration method and continuous contact with our patients, we strive to attain exceptional results. Certain treatments, including intravitreal injection of antivascular endothelial growth factor, have shown considerable success in slowing disease progression and reducing the number of blind people worldwide by preventing further . This improvement persisted for at least 2 months in terms of both within- and between-group comparisons. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. 6, pp. The sample size calculation was based on results of two earlier pilot studies at the Institute of Medical Psychology considering similar patients and equivalent stimulation schemes, i.e., rtACS- and sham-groups as in the present trial. the detection rate at a given visual field position . One serious adverse event with subsequent hospitalization occurred, but it was unrelated to rtACS. S niezbdne do dziaania witryny i nie mona ich wyczy w naszych systemach. But stem cell transplantation was only tried in few patients and is not ready for wide scale clinical application . I'm not a doctor so take this with a grain of salt but I also recall being told that it is FDA approved. The following etiologies of optic atrophy were also included: post-acute inflammation (n = 12), optic nerve compression (n = 5, of which 4 were tumor-induced and 1 intracranial hemorrhage), congenital or unknown etiology of optic atrophy (n = 5), and Leber's hereditary optic neuropathy (n = 3). Further secondary endpoints were static and kinetic perimetry results (foveal and mean threshold of 30-VFs, mean eccentricity/VF size), best corrected near and far visual acuity (Landolt), and patient-reported outcome, i.e., an intervention-related questionnaire with a structured response format and a vision-related QoL questionnaire (NEI-VFQ-39) [18] to evaluate subjective improvements of visual field defect and related impairments (15 items) and general health and mental distress (four items) at POST and FOLLOW-UP. For further explanations, see text. Authors: Sabel, Bernhard A.a * | Flammer, Josefb | Merabet, Lotfi B.c, Affiliations: Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany | Department of Ophthalmology, University of Basel, Basel, Switzerland | Department of Ophthalmology, The Laboratory for Visual Neuroplasticity, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA. Primary and secondary endpoints were defined prospectively. Yes No. Some exploratory reports show that certain drugs might be able to improve visual fields. Transient vertigo was reported by two rtACS-subjects in a total of five sessions and one sham-subject experienced persistent vertigo for 0.5 hrs after each session. I was very impressed with the professional care that I received at the Clinic. Fedorov restoration therapy Berlin? Reaction time changes in HRP improved in the rtACS-group (median) by 8ms, (CI[-16;0], p = 0.023), with a trend in the sham-group of 4ms (CI[-15;2], p = 0.069); the between-group difference was not significant (p = 0.35). The percentage of reactions outside the valid response window (1501000ms) after stimulus presentation in HRP increased slightly after rtACS (0.3%, CI[0.0; 0.9], p = 0.016) and remained unchanged after sham (-0.03%, CI[-0.5; 0.2], 0.377) with a significant difference between groups (p = 0.033). The median between-group difference in percentage detection rate change in the defective VF did not reach statistical significance, (8.2% CI[-5.9%;22.5%, p = 0.131) because this parameter significantly increased in both groups; by 41.3% (CI[31.5; 54.3]) in the rtACS- and 33.2% (CI[23.4; 44.2]) in the sham-group (both p<0.001). The size of the absolute defect significantly decreased after rtACS when compared to sham-treated patients ( = 190.201, df = 1, p<0.0001) (S2 Fig). 10.1016/B978--444-53355-5. . Future studies might use high-density EEG, which would allow using source reconstruction algorithms (e.g. Denn bei einer dauerhaften Erhhung, wenn das Kammerwasser aus dem Auge also am Abflieen gehindert wird, kann es durch den stndigen berdruck zu Schden an der Netzhaut kommen, die sich sehr oft auf den Ansatzpunkt des Sehnervs und den Punkt des Schrfsten Sehens konzentrieren. Neurology 2004; 63: 2069-76 . Computer simulations of current flow in the intact brain suggest that a considerable amount of current enters the skull through the eye and optic nerve (Fig 3A), affecting brain regions close to the eye socket. full function, partial function and absolute vision loss) were determined by superimposing repeated HRP measures to determine which visual field regions are intact, partially damaged (residual I and residual II) and absolutely impaired (absolute defect). It's also extremely difficult to remove bad reviews (Which I'm sure they would have had if what they were selling snake oil). Nervous system degeneration in aging can affect the structure and function anywhere along the visual eye-to-brain axis . The therapy works by stimulating the brain to form new connections, according to NovaVision, the device's manufacturer. Right sub-figure: Scatter plot showing the relation between change in alpha band coherence at the occipital area of interest and change in detection accuracy in total visual field (primary outcome measure). Other neuropsychiatric disorders with visual system disturbance are psychosis/schizophrenia, autism, and dyslexia . The effects of rtACS or sham-stimulation on EEG measures were analyzed as EEG = EEGpostEEGpre. . The trial flow diagram and study design are shown in Fig 1A and 1B. Of 98 eligible patients, 45 were treated with rtACS and 37 with sham-stimulation. Partial vision loss, with sometimes considerable residual vision is by far more prevalent than total vision loss. Contact us: healthyeyestalk.com, Video Testimonial Fedorov Restore Vision Clinic, If its possible for you to get better eyesight with. On a systems level, the brain, by releasing stress hormones influence vascular tone, particularly in and around the optic nerve and thereby impair vascular autoregulation and perfusion of the whole body, including itself and that of the eyes . Reddit, Inc. 2023. Target stimuli (size: III/4mm2, white, luminance: 318 cd/m2/ 0db, duration: 0.2 sec) were presented on a background with constant luminance of 10cd/m2. Ihre Sehkraft hat bereits sehr stark abgenommen und nichts wrden Sie sich sehnlicher wnschen, als endlich Ihre Umwelt wieder besser wahrnehmen zu knnen? https://doi.org/10.1371/journal.pone.0156134.g002. Scan this QR code to download the app now. It may be argued that visual improvements after rtACS can be explained by perceptual learning due to repeated testing. [Google . To conceal group identity, sham-patients received only one ACS burst per minute (minimal stimulation) to create phosphene experiences. 1,456 likes. I was so impressed with my results from June 2017 that I returned this May 2018 and again am thrilled with my results. Mental health in Germany: services and support | Expatica No, Is the Subject Area "Visual acuity" applicable to this article? Fedorov Therapy isn't aimed at the replacement of . They have many positive TRACEABLE Google and Facebook reviews. Improvements in the performance of the Trail Making Test were observed in both groups. High vs. low defect depth was defined as stimulus detection rates below vs. above 30% inside the VF defect. Attentional cueing improves vision restoration therapy in patients with visual field defects. The reason we selected a minimal dose treatment for sham controls is that this equalizes the expectations in both groups. Indeed, one would not expect that patients generate a hypothesis on their own that fewer phosphenes were less effective. Fedorov Restoration Therapy is an interdisciplinary approach that combines the sciences of Ophthalmology and Neurology. Secondary endpoints of HRP were percentage change of the stimulus detection rate in the defective VF (excluding intact areas), the central 5-VF, and average reaction time in total HRP VF. Fedorovs restorative therapy is an interdisciplinary approach that combines the knowledge of ophthalmology and neurology. For more information, please see our The difference between groups in the primary outcome measure was found to be maily caused by a reduction of the absolute (black) scotoma region in the rtACS-group. Repeated daily stimulation with non-invasive rtACS significantly improved detection performance in VFs with persistent effects for at least 2 months beyond the stimulation period as shown by static perimetry. Our treatment is recommended for patients suffering from any optic nerve atrophy but especially damage originating as glaucomatous, ischemic, traumatic, inflammatory, post tumor, or hydrocephalus induced optic neuropathies. In order to analyze which areas of the visual field respond with improvements after rtACS, we separately analyzed different visual field states based on HRP measurements and developed a treatment outcome prediction model to predict from the BASELINE results of HRP visual fields the extent of vision restoration . Yes Here, repetitive transorbital alternating current stimulation (rtACS) was applied in partially blind patients with the goal of activating their residual vision. ), 2 sec bins, and baseline correction. Dont Miss: Night Vision Security Camera System. Briefly, clinical trials on axonal regeneration, though promising experimentally, have not been carried out due to the still too limited regeneration potential . No, PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US, Corrections, Expressions of Concern, and Retractions, https://doi.org/10.1371/journal.pone.0156134. Privacy Policy. alternating current stimulation; CSF, In the first trial a mean percentage increase ( standard deviation) of 65.61 104.35 was observed in the rtACS-group (n = 19) and 16.93 31.22 in the sham-group (n = 14). The Fedorov Restore Vision Clinic is located in the heart of this beautiful city, with first-class museums, art galleries, enticing shops, scrumptious restaurants, nightclubs, and many world-famous historical attractions like the Berlin Wall and Berlin Palace, ensuring you will not leave disappointed. The authors confirm that all ongoing and related trials for this intervention are registered. repetitive transorbital alternating current stimulation; VF, Other secondary outcome measures obtained at POST did not reveal significant between-group differences. Although the simulation model does not consider the extent of optic nerve damage the results provide meaningful insights indicating that most of the current affect frontal parts of the brain including eyeball and optic nerve while only low levels were found in the visual cortex. My wife had brain tumor removed and she is losing her eyesight. Yet, the level of clinical evidence is still not definitive because the trials included only small patient samples [12,1416]. FOLLOW-UPBASELINE) / BASELINE. Drugs that improved the visual fields of glaucoma patients had the following characteristics and limitations: the short-term changes were not related to IOP changes one could observe threshold shifts in relative scotomas , but very rarely though occasionally changes in the size of absolute scotomas, all the drugs that improved VF had in common that they improved blood flow in the eye , and improvements were more likely seen in FS+ but only infrequently in FS- cases . Subjective change was evaluated with the NEI-VFQ scales visual field defect and related impairments and general health and mental distress at POST and FOLLOW-UP and compared between groups. With this innovative method, it is possible to improve vision with the help of electrical stimulation. For more information about PLOS Subject Areas, click This finding is compatible with the hypothesis that cortical EEG changes after rtACS are due to physiological synchronous activation of retinal ganglion cells following eye and optic nerve stimulation [25]. In fact, performance change in HRP correlated negatively with changes in deviations from fixation during eye-tracked HRPs, i.e. By sheer luck, I found Restore Vision Clinic in Berlin and received treatment there. Below phosphene-threshold stimulation was employed by others [37]. Wrote the paper: CG AA BAS SS SAB. Primary data analysis was conducted independently by the biometry department of two of the coauthors (A.L., S.K.) Our findings of improved visual functions are consistent with the hypothesis that rtACS can modulate perceptual thresholds in areas of residual vision as previously reported in studies that also used current stimulation [12, 1416] or behavioral vision training methods [10, 17, 2628]. Fedorov restoration therapy Berlin? Any good? : r - Reddit Due to the possibility that patients with monocular impairment may not experience a severe reduction in vision-related QoL, an exploratory subgroup analysis of patients with binocular loss, i.e., excluding those with an intact fellow eye, was conducted. Since we observed a decrease in RT when ACS treated patients responded to small light stimuli presented during visual field testing, another alternative explanation for improved vision outcome is a secondary effect of an increase in attention in the treatment group due to rtACS which then results in general performance improvements in vision tests as well. Our treatment has also proven successful in cases of underdeveloped optic nerves . (A) Primary and secondary analyses of VF outcome between- and within-groups after rtACS and sham-stimulation bar charts of primary (first upper graph) and secondary parameters of VF diagnostics measured using HRP and standard-automated static and kinetic perimetry. For future studies in this area current flow simulations may help to target both safety considerations and improved stimulation paradigms. The procedure included a fixation control using isoluminant color changes of the fixation point. Indeed, the sham group significantly improved in some parameters as well. It is the next chapter in organ transplantation and uses cells instead of donor organs, which are limited . Results of a structured intervention-related questionnaire that also included a response category labeled not sure. Post-intervention changes in the intact and residual visual field did not differ between groups. This equates to 17.8 million people. To conceal group identity, sham-patients received only one ACS burst per minute to create phosphene experiences. Wireless Outdoor Cameras With Night Vision. Fedorov Restoration Therapy, Berlin, Germany. We performed computer simulation to estimate the amount of current that was being delivered to components of the visual system in a 40-yrs old male control subject. Though the studies were not randomized trials, they still offer some clues for future research: FS patients treated with calcium channel blockers or acetazolamide to increase blood flow who rapidly improved visual field function. Patients can do outdoor exercise therapy or simply take a walk through the hospital's scenic grounds. Vision Restoration Therapy (VRT) - NovaVision Yes Get started on your journey of vision recovery today. Kaia Health | 22,453 followers on LinkedIn. In subjects with binocular vision impairment, NEI-VFQ measures of vision-related QoL indicated improved ratings of NEI-VFQ scales VF defect and related impairments after rtACS as well as improved ratings of general health and mental distress after sham. Therefore, the current flow simulation was done only with one electrode, representing all other electrodes. The 10.2% between-group difference at FOLLOW-UP was significant at p = 0.01 (CI[1.4%;22.8]). Ischemic Optic Neuropathy. We can help. - Restore Vision Clinic None of the participants reported discomfort during the stimulation. However, the draw-back of this kind of sham procedure is that a minimal dose may actually have some, albeit small, therapeutic effects that cannot be separated from possible placebo effects of the current study design. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. We learned that vision impairment is very serious condition, affecting many areas of everyday life. The primary outcome measure for efficacy was super-threshold visual fields with 48 hrs after the last treatment day and at 2-months follow-up. HRP reaction time (absolute differences), visual acuity (logarithmic values) and questionnaire data were shown as absolute values. Blokowanie niektrych rodzajw plikw cookie moe wpyn na komfort korzystania z witryny i usug, ktre jestemy w stanie zaoferowa. (B) Individual change in HRP VF charts at BASELINE and POST in the two best responding patients of both groups. Kaia Health | LinkedIn The proposed mechanism of action is neuromodulation of oscillatory brain activity towards a more synchronized EEG via entrainment of specific stimulation frequencies [1011], and the reorganization of brain functional connectivity networks [12] is considered to be a novel and promising avenue for visual rehabilitation [13]. A finite element model was developed using multi-modal imaging data (MRI/CT) of a 40-yrs-old male. The ethics committees of the participating study centers in Magdeburg, Berlin, and Goettingen approved the study, and a statistical analysis plan was filed with the lead ethics committee. Informacje nie identyfikuj uytkownika, ale mog zapewni bardziej spersonalizowan obsug w sieci. What is stem cell therapy (regenerative medicine) and how does it work? With respect to BASELINE variables, results did not significantly differ between the rtACS- and the sham-group (Table 2). Ask Our Physicians For Your Evaluation How does Fedorov Restoration Therapy work? No, Is the Subject Area "Brain damage" applicable to this article? In kinetic perimetry the VF border was determined for 24 meridians (spaced by 15) in randomized order at a constant luminance threshold of III/4e (0dB) and a velocity of 2 per sec. Mean eccentricity refers to the average of 24 meridians. (A) Patient flow for cases included in the primary outcome measure analysis. Out of a total of 12 features deemed relevant based on previous studies , two features of HRP visual fields at baseline were associated with visual field improvements after rtACS: greater neighborhood activity, i.e., the mean detection rate of all HRP test positions within a 5 radius around each detected location, and greater residual function, i.e. Background. Dafr bieten wir das gesamte Spektrum der klassischen Augenuntersuchungen: beispielsweise fr die Bestimmung der Sehschrfe und der Refraktion, also der Gesamtbrechkraft des visuellen Systems und seiner individuellen Parameter bezogen auf das rechte und linke Auge. Recommended Reading: Double Vision When Looking Down, 2022 HealthyEyesTalk.com After 10 days rtACS, the mean threshold in static perimetry (median change 9.3%; CI[2.6;20.3], p = 0.003) significantly increased while after sham-stimulation no significant change in threshold in static perimetry was noted (median change 1.9%; CI [-4.8%, 8.8%]). I can also see from Google Scholar that the papers have been cited multiple times. Devon Schuyler Vision Restoration Therapy (VRT) is an FDA-cleared device for treatment of visual field defects caused by stroke or traumatic brain injury. ACS, Reliability parameters of HRP and eye-tracking documented excellent retinotopic reliability of the primary outcome measure, validating that improved visual detection could not be explained by altered eye movements (S2 Fig). Further reports were mild headaches immediately after a stimulation session by four rtACS- and two sham-subjects and cutaneous sensations in eight sham- and 12 rtACS-subjects. The absolute change of HRP fixation accuracy and percentage of responses outside the valid response window in HRP were considered as reliability parameters. In a darkened room, the patient was viewing a 17" monitor from a chin-head-rest at a distance of 42 cm. Four 10mm Grass gold electrodes (SAFELEAD, Astro-Med, Inc, USA), 2 for each eye, were placed on the skin near the orbital cavity (transorbital), and biphasic square-pulses were applied in bursts (Alpha SYNC stimulator, EBS Germany). However, only 18.9% of these people seek assistance from service providers. Within-group comparisons were calculated with Wilcoxon matched-pairs signed rank-tests. With this approach, more than 75% of our Restore Vision Clinic patients respond well after only one course of treatment . Interestingly, Wostyn, Audenaert & De Deyn argue that AD also shares certain features with glaucoma in that both conditions lead to RGC death. Middle sub-figure: After sham stimulation a significant power increase was observed for only the theta band (Z = 3.147, p = 0.002). Only after a favourable assessment of your medical records will you be invited to Germany to undergo treatment. PLOS ONE promises fair, rigorous peer review, visual field. I found their details online after pretty much giving up and resigning my self to being blind in the near future. Five subjects left the study between initial screening and BASELINE for different reasons and another five subjects were excluded due to violation of an inclusion criterion (unacceptable fluctuations between initial screening and BASELINE). Because well-synchronized dynamic brain networks are critical for cognitive processing of visual information [30], we conclude that a visually deprived brain with re-synchronized functional networks can process reduced visual input more efficiently thereby activating or amplifying, residual vision even many years after the damage has occurred [10]. VF mapping was conducted using a campimetric, high-resolution, super-threshold visual detection test (HRP) [17], a method that reveals areas of residual vision in the central VF with lower inter-test-variability than standard static perimetry due to target luminance above threshold. Between-group comparisons were conducted with independent samples t test. I think this is more suited to AskScienceDiscussion than AskScience. Table 3 summarizes the results of the trial. Linda J FortierCalifornia, United StatesBruce HerouxAlberta, Canada. More than 75 per cent of the patients notice an improvement in vision after one course. 6,529,759. After BASELINE assessments patients were stimulated with either rtACS or sham-stimulation on 2 5 weekdays for 25 min at day1 to 50 min at day10 with eyes closed. 1. Non-invasive electrical stimulation for vision restoration: dream or